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公司基本資料信息
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| 產(chǎn)品編號 | MAV115 |
|---|---|
| 產(chǎn)品名稱 | Recombinant Human anti-COVID-19/SARS-CoV-2 S1 Monoclonal Antibody |
| 抗體亞型 | IgM |
| 規(guī)格與價格 | 100ul/￥2,300; 500ul/￥6,500 |
| 克隆號 | 3D6 |
| 產(chǎn)品別名 | SARS-CoV-2 S1 protein antibody, 2019-nCoV, Coronavirus |
| 規(guī)格 | 100ul, 500ul |
| 物種 | COVID-19 |
| 宿主 | Human |
| 產(chǎn)品應(yīng)用 | ELISA, Colloidal Gold, POCT, Neutralizaiton , Standard Positive Control |
| 內(nèi)毒素水平 | <0.1EU/ug determided by LAL method. |
| 緩沖體系 | 0.01M PBS, pH 7.4 |
| 免疫原 | Native virus |
| 產(chǎn)品背景 | A novel severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) recently emerged and is rapidly spreading in humans, causing COVID-19. A key to tackling this pandemic is to understand the receptor recognition mechanism of the virus, which regulates its infectivity, pathogenesis and host range. SARS-CoV-2 and SARS-CoV recognize the same receptor—angiotensin-converting enzyme 2 (ACE2)—in humans. Researchers determined the crystal structure of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 (engineered to facilitate crystallization) in complex with ACE2. In comparison with the SARS-CoV RBD, an ACE2-binding ridge in SARS-CoV-2 RBD has a more compact conformation; moreover, several residue changes in the SARS-CoV-2 RBD stabilize two virus-binding hotspots at the RBD–ACE2 interface. These structural features of SARS-CoV-2 RBD increase its ACE2-binding affinity. Additionally, we show that RaTG13, a bat coronavirus that is closely related to SARS-CoV-2, also uses human ACE2 as its receptor. |
| 保存條件 | This product can be stored at 2℃-8℃ for one month. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
| 備注 | This product is used for research use only. Not for human or diagnostic use. |
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